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- Title
Advocating for better trials in rheumatology.
- Authors
Kaushik, Sharanya; Junek, Mats; Putman, Michael
- Abstract
The article comments on the ADVOCATE randomized trial which compared the C5a inhibitor avacopan and placebo in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Topics discussed include induction therapy with cyclophosphamide followed by azathioprine as maintenance therapy or rituximab with no maintenance therapy, the primary end point of the treatment and the difficulty in interpreting outcomes due to inadequate maintenance therapy.
- Subjects
GLUCOCORTICOIDS; RITUXIMAB; ADRENOCORTICAL hormones; AZATHIOPRINE; RHEUMATOLOGY; CYCLOPHOSPHAMIDE; DISEASE remission
- Publication
Rheumatology, 2023, Vol 62, Issue 12, p3776
- ISSN
1462-0324
- Publication type
Editorial
- DOI
10.1093/rheumatology/kead459