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- Title
Roadblocks confronting widespread dissemination and deployment of Organs on Chips.
- Authors
Alver, Charles G.; Drabbe, Emma; Ishahak, Matthew; Agarwal, Ashutosh
- Abstract
Organ on Chip platforms hold significant promise as alternatives to animal models or traditional cell cultures, both of which poorly recapitulate human pathophysiology and human level responses. Within the last 15 years, we have witnessed seminal scientific developments from academic laboratories, a flurry of startups and investments, and a genuine interest from pharmaceutical industry as well as regulatory authorities to translate these platforms. This Perspective identifies several fundamental design and process features that may act as roadblocks that prevent widespread dissemination and deployment of these systems, and provides a roadmap to help position this technology in mainstream drug discovery. Organ on Chip platforms hold significant promise as alternatives to traditional animal models or cell cultures. In this Perspective, the authors examine the barriers that prevent widespread dissemination and deployment of these systems.
- Subjects
MICROPHYSIOLOGICAL systems; DRUG discovery; COLLEGE laboratories; CELL culture; ANIMAL models in research; PHARMACEUTICAL industry
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-48864-3