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- Title
ANALYSIS OF CD10 EXPRESSION IN THE EPITHELIAL LINING OF ODONTOGENIC CYSTS.
- Authors
Ali, Anam; Asif, Muhammad; Ali, Iram; Ahmad, Bismah; Khadim, Muhammad Tahir; Akhtar, Farhan; Abbasi, Muhammad Sajjad
- Abstract
Objective: To investigate the expression of CD10 in the epithelium of Odontogenic keratocyst (OKC), Dentigerous and radicular cyst. Study Design: Cross sectional analytical study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jan 2017 to Dec 2017. Methodology: In this study, total of sixty cases were included with 20 of each Radicular cyst, Dentigerous cyst and Odontogenic keratocyst. Sections were stained with Haematoxylin and eosin (H&E) followed by Immunohistochemistry (IHC) staining for CD10 antibody. SPSS version 20 was used to analyse the results. Expression of CD10 was evaluated. Results: Out of total 60 cases, 41 (68.3%) were male and 19 (31.7%) were female patients with age ranges from 11 to 75 years. Mandible was reported in 38 (63.3%) of the cases followed by maxilla in 22 (36.7%) of the cases. In this study 7 (38%) cases of Odontogenic keratocysts showed negative epithelial CD10 expression as compared to Dentigerous cysts and Radicular cysts (45% & 25%). In Odontogenic keratocysts 9 (45%) of the cases showed basal layer of positivity of epithelium. While in dentigerous cyst 11 (55%) of the cases showed CD10 expression in the superficial layer of epithelium and the entire epithelium was positive in almost all 15 (75%) cases of radicular cyst. Intensity of staining was moderate in maximum number of the cases of Odontogenic keratocyst and radicular cyst (40% & 35%) as compared to dentigerous cyst (20%). There was a statistically significant association between odontogenic cysts and epithelial CD10 expression (p=0.001). Conclusion: Majority of odontogenic cysts showed positivity for CD10 marker. Odontogenic keratocysts showed basal, DCs showed surface and RCs showed full thickness positivity for this marker.
- Subjects
RAWALPINDI (Pakistan); ODONTOGENIC cysts; DENTIGEROUS cyst; RADICULAR cyst; ARMED Forces
- Publication
Pakistan Armed Forces Medical Journal, 2020, Vol 70, pS10
- ISSN
0030-9648
- Publication type
Article