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- Title
Analysis of Increased EGFR and IGF-1R Signaling and Its Correlation with Socio-Epidemiological Features and Biological Profile in Breast Cancer Patients: A Study in Northern Brazil.
- Authors
Rocha, Francianne Silva; da Silva Maués, Jersey Heitor; Pereira, Cynthia Mara Brito Lins; Moreira-Nunes, Caroline Aquino; Burbano, Rommel Mário Rodriguez
- Abstract
Introduction: Breast cancer (BC) is the second most frequent cancer worldwide. It is known that a subset of BC has amplification, and overexpression of the epidermal growth factor receptor (EGFR) and high expression of the insulin-like growth factor receptor-1 (IGF-1R) are correlated with a favorable prognosis. This study aimed to evaluate the prognostic and predictive values of the EGFR and IGF-1R in tumor samples from patients with BC and their correlation with socio-epidemiological features. Patients and Methods: We analyzed socio-epidemiological, clinical–pathological data and tumor tissues from 124 patients with BC undergoing treatment, to assess levels of EGFR and IGF-1R mRNA and protein. The predictive performance included the calculation of area-under-the-curve (AUC) to discriminate groups of patients with high and low mRNA expression associated with survival analysis within each molecular group of BC. Results: We found a significant expression increase (p < 0.001) in EGFR associated with body mass index, angiolymphatic invasion, compromised lymph nodes and follow-up in 58.1% of the triple-negative and HER overexpression tumors. The increase in IGF-IR was significant (p < 0.001) in 41.9% of luminal tumors A and B. ROC analysis showed that EGFR had a higher predictive performance (AUC = 0.891) than IGF-1R (AUC = 0.60). The Kaplan–Meier analysis indicated that only the high expression of EGFR was associated with a decreased probability of survival for patients, what did not happen with IGF-1R. Conclusion: Our results suggest that EGFR and IGF-1R expression patterns associated with the clinical characteristics of patients and biological profile influenced the evolution of BC.
- Subjects
BRAZIL; EPIDERMAL growth factor receptors; SOMATOMEDIN; BREAST cancer; CANCER patients; LYMPHATIC metastasis
- Publication
Breast Cancer: Targets & Therapy, 2021, Vol 13, p325
- ISSN
1179-1314
- Publication type
Article
- DOI
10.2147/BCTT.S308554