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- Title
Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship.
- Authors
Yang, Kang; Liu, Di; Feng, Lei; Xu, Liugen; Jiang, Yangang; Shen, Xiran; Ali, Amjad; Lu, Jianwei; Guo, Li
- Abstract
The development of nontoxic and efficient antifreeze agents for organ cryopreservation is crucial. However, the research remains highly challenging. In this study, we designed and synthesized a series of peptoid oligomers using the solid-phase submonomer synthesis method by mimicking the amphiphilic structures of antifreeze proteins (AFPs). The obtained peptoid oligomers showed excellent antifreeze properties, reducing the ice crystal growth rate and inhibiting ice recrystallization. The effects of the hydrophobicity and sequence of the peptoid side chains were also studied to reveal the structure–property relationship. The prepared peptoid oligomers were detected as non-cytotoxic and considered to be useful in the biological field. We hope that the peptoid oligomers presented in this study can provide effective strategies for the design of biological cryoprotectants for organ preservation in the future.
- Subjects
ANTIFREEZE solutions; ANTIFREEZE proteins; PRESERVATION of organs, tissues, etc.; SOLID-phase synthesis; CRYSTAL growth; OLIGOMERS; ICE crystals
- Publication
Polymers (20734360), 2024, Vol 16, Issue 7, p990
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym16070990