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- Title
A brief review: adipose-derived stem cells and their therapeutic potential in cardiovascular diseases.
- Authors
Teng Ma; Jiacheng Sun; Zhenao Zhao; Wei Lei; Yueqiu Chen; Xu Wang; Junjie Yang; Zhenya Shen
- Abstract
Adipose-derived stem cells (ADSCs) are easily obtained and expanded, and have emerged as a novel source of adult stem cells for the treatment of cardiovascular diseases. These cells have been shown to have the capability of differentiating into cardiomyocytes, vascular smooth muscle cells, and endothelial cells. Furthermore, ADSCs secrete a series of paracrine factors to promote neovascularization, reduce apoptosis, and inhibit fibrosis, which contributes to cardiac regeneration. As a novel therapy in the regenerative field, ADSCs still face various limitations, such as low survival and engraftment. Thus, engineering and pharmacological studies have been conducted to solve these problems. Investigations have moved into phase I and II clinical trials examining the safety and efficacy of ADSCs in the setting of myocardial infarction. In this review, we discuss the differentiation and paracrine functions of ADSCs, the strategies promoting their therapeutic efficacy, and their clinical usage.
- Subjects
FAT cells; CARDIOVASCULAR disease treatment; HEART cells; MUSCLE cells; MYOCARDIAL infarction
- Publication
Stem Cell Research & Therapy, 2017, Vol 8, p1
- ISSN
1757-6512
- Publication type
Article
- DOI
10.1186/s13287-017-0585-3