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- Title
Animal Models to Study Emerging Technologies Against SARS-CoV-2.
- Authors
Mullick, Jhinuk Basu; Simmons, Chelsey S.; Gaire, Janak
- Abstract
New technologies are being developed toward the novel coronavirus SARS-CoV-2 to understand its pathogenesis and transmission, to develop therapeutics and vaccines, and to formulate preventive strategies. Animal models are indispensable to understand these processes and develop and test emerging technologies; however, the mechanism of infection for SARS-CoV-2 requires certain similarities to humans that do not exist in common laboratory rodents. Here, we review important elements of viral infection, transmission, and clinical presentation reflected by various animal models readily available or being developed and studied for SARS-CoV-2 to help bioengineers evaluate appropriate preclinical models for their emerging technologies. Importantly, applications of traditional mice and rat models are limited for studying SARS-CoV-2 and development of COVID-19. Non-human primates, Syrian hamsters, ferrets, cats, and engineered chimeras mimic the human infection more closely and hold strong potential as animal models of SARS-CoV-2 infection and progression of resulting human disease.
- Subjects
SARS-CoV-2; TECHNOLOGICAL innovations; ANIMAL models in research; VIRUS diseases; COVID-19; FELIDAE
- Publication
Cellular & Molecular Bioengineering, 2020, Vol 13, Issue 4, p293
- ISSN
1865-5025
- Publication type
Article
- DOI
10.1007/s12195-020-00638-9