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- Title
A critical review on food protein derived antihypertensive peptides.
- Authors
Premkumar, Jayapal; Malini, M.; Joshy, V. Arun
- Abstract
Protein hydrolysates prepared from food sources are known to contain potent biologically active peptides. Bioactive peptides are highly used to treat a number of health related diseases. Antihypertensive activity is the most studied till date, with bioactive peptides derived from food protein reported to have an edge over synthetic drugs. Food protein-derived peptides with specific sequences inhibit the angiotensin-converting enzyme-I (ACE-I), the major target for controlling elevated blood pressure levels. Mostly, the peptides with competitive inhibitor mode would inhibit the ACE-I effectively than noncompetitive and uncompetitive modes. The emerging technologies in drug discovery studies, facilitates the drug development process easier, even though the technologies provide a better platform for drug discovery, the more precise clinical and control measures are needed for effective release, and functioning at target sites of food-derived bioactive peptides in the human gastrointestinal system.
- Subjects
PEPTIDES; ANGIOTENSIN I; PROTEIN hydrolysates; GASTROINTESTINAL system; BLOOD pressure; SYNTHETIC drugs
- Publication
Drug Invention Today, 2019, Vol 12, Issue 3, p474
- ISSN
0975-7619
- Publication type
Article