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- Title
Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice.
- Authors
Minderis, P.; Kilikevicius, A.; Baltusnikas, J.; Alhindi, Y.; Venckunas, T.; Bunger, L.; Lionikas, A.; Ratkevicius, A.
- Abstract
The aim of the study was to investigate if myostatin dysfunction would promote the gain in muscle mass and peak isometric force ( P0) of soleus muscle ( SOL) in response to functional overloading ( FO) after ablation of the gastrocnemius muscle. Fifteen male Berlin high ( BEH) mice homozygous for the compact mutation causing dysfunction of myostatin and 17 mice with the corresponding wild-type allele ( BEH+/+) were subjected to FO of SOL for 28 days at the age of 14 weeks. Compared with BEH+/+ mice, SOL of BEH was heavier (mean ± SD, 13.5 ± 1.5 vs 21.4 ± 1.8 mg, respectively, P < 0.001). After FO, SOL mass increased relatively more in BEH+/+ than BEH strain (34.9 ± 11.5 vs 17.7 ± 11.9%, respectively, P < 0.01). P0 fell ( P < 0.01) only in BEH strain, which also showed an increase ( P < 0.01) in optimal muscle length. Specific P0 became even more depressed in BEH compared with BEH+/+ strain (8.4 ± 1.4 vs 10.8 ± 1.3 N/g, respectively, P < 0.001). Phosphorylation p70 S6 kinase did not differ between the strains. In summary, myostatin dysfunction impairs adaptation of SOL muscle to high functional demands.
- Subjects
PHYSIOLOGICAL adaptation; ALLELES; ANIMAL experimentation; GENETICS; HYPERTROPHY; DIGITAL image processing; MICE; MUSCLE contraction; MUSCLE strength; PROBABILITY theory; RESEARCH funding; STATISTICAL hypothesis testing; WEIGHTS &; measures; WESTERN immunoblotting; CALF muscles; DATA analysis software; DESCRIPTIVE statistics; MYOSTATIN; RESISTANCE training
- Publication
Scandinavian Journal of Medicine & Science in Sports, 2016, Vol 26, Issue 8, p894
- ISSN
0905-7188
- Publication type
Article
- DOI
10.1111/sms.12532