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- Title
YOLK SAC TUMOR: CASE REPORT OF AN UNUSUAL PRESENTATION.
- Authors
Constantin, Gabriela; Chincesan, Mihaela Ioana; Derzsi, Zoltan; Horvath, Emoke
- Abstract
Background: Yolk sac tumor is a malignant germ cells tumor, whose incidence rises with age, and whose predominant localization is the ovary or testicle, but it can have predilection to extragonadal sites too. Despite the fact that is an aggressive tumor, the response to treatment is favorable. Objective: The aim of this presentation is to highlight the importance of early diagnosis and oncological team in management of this disease. Material and methods: A 10-month-old boy with no personal physiological history was admitted at the emergency service presenting altered general status, inappetence, psychomotor agitation. The physical examination revealed the presence of a tumor mass in the right inguinal region, with increased consistency, adherent to the adjacent musculo-fascial plane. Results: Computer Tomography (CT) revealed multiple pelvic and right inguinal tumoral masses measuring 50x82 mm in the greatest dimension and secondary pulmonary, limfonodular, dural determinations. A biopsy was performed from the inguinal tumor and following the extemporaneously exam, a malignant process was confirmed. The values of tumor markers, alpha-fetoprotein (AFP) and beta human chorionic gonadotropin (hCG) were >50000 UI/ml and 0,1 Miu/ml, respectively. Hematoxilin Eosin (HE) stained sections from paraffin embedded tumoral tissue revealed a microcystic histologic pattern containing primitive tumor cells with varying amounts of clear, glycogenated cytoplasm, occasionally containing lipid, eosinophilic hyaline globules, Schiller-Duval bodyes, tumor necrosis and foci of hemorrhage and inflammatory infiltrate. Immunohistochemical stains showed immunoreactivity to AFP, SALL 4 and Keratin AE1/AE3. Conclusion: the particularity of the case consists in the primary localization of the tumor that is externalized by the inguinal mass mimicking an adenopathy. In children under one year any tumour mass should be considered malignant and fully investigated.
- Subjects
YOLK sac; GROIN; CHORIONIC gonadotropins; CANCER; NEUROECTODERMAL tumors; GERM cell tumors; TUMOR markers
- Publication
Acta Medica Marisiensis, 2019, Vol 65, p44
- ISSN
2068-3324
- Publication type
Article