We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice.
- Authors
Ito, Takashi; Oishi, Shohei; Takai, Mika; Kimura, Yasushi; Uozumi, Yoriko; Fujio, Yasushi; Schaffer, Stephen W.; Azuma, Junichi
- Abstract
Taurine, a sulfur-containing β-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardiac and skeletal muscles. Meanwhile, taurine deficiency leads various pathologies, including dilated cardiomyopathy, in cat and fox. However, the essential role of taurine depletion on pathogenesis has not been fully clarified. To address the physiological role of taurine in mammalian tissues, taurine transporter-(TauT-) knockout models were recently generated. TauTKO mice exhibited loss of body weight, abnormal cardiac function and the reduced exercise capacity with tissue taurine depletion. In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice.
- Subjects
TAURINE; MYOCARDIUM; CELL physiology; LABORATORY mice; ETIOLOGY of diseases
- Publication
Journal of Biomedical Science, 2010, Vol 17, p1
- ISSN
1021-7770
- Publication type
Article
- DOI
10.1186/1423-0127-17-S1-S20