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- Title
Production of Multilayer Nanofibers Through Polyvinyl Alcohol/Parrotia Persica Extract and Polycaprolactone Combination.
- Authors
Ranjbar-Mohammadi, Marziyeh; Shiralipour, Mahsa
- Abstract
In recent times, there has been a burgeoning interest in harnessing natural plant extracts for the development of innovative biological scaffolds. This article centers on the extraction of Parrotia persica extract and explores its potential suitability for integration into nanofibrous structures. In pursuit of this objective, nanofibers were meticulously crafted using a blend of polyvinyl alcohol (PVA) and the derived Parrotia persica extract (E), employing the electrospinning technique. Different PVA/E ratios (90:10, 80:20, and 50:50) were investigated. The formation of layer-by-layer structures (four layers) was achieved by sequentially electrospinning a layer of PCL nanofibers onto a collector, followed by the deposition of a layer of PVA/E ((80:20) and (50:50)) with the identical thickness. The results revealed that the layered fibers exhibited a strikingly three-dimensional architecture, closely resembling the natural extracellular matrix. Notably, among the samples, the PCL-PVA/E (80:20)-PCL composition demonstrated the most favorable morphology, featuring a contact angle of approximately 40.45° and a diameter measuring 403 nm. Fourier transform infrared spectroscopy (FTIR) analysis conclusively confirmed the presence of Parrotia persica extract, PVA, and PCL within the intricate layers. Furthermore, fibroblast cell culture observations revealed the attachment and spreading of cells on the surface of the PVA/E (80:20)-PCL samples, underscoring their potential for facilitating cellular growth and tissue regeneration.Taking into account their highly desirable hydrophilic properties, the incorporation of Parrotia persica extract with its antibacterial and antioxidant attributes, as well as the presence of PCL endowed with elastic properties akin to those of natural skin, the prepared nanofibrous structures exhibit a promising outlook as viable skin substitutes.
- Subjects
POLYCAPROLACTONE; POLYVINYL alcohol; FOURIER transform infrared spectroscopy; NANOFIBERS; CELL culture; ELASTICITY; CELL growth; CONTACT angle
- Publication
Arabian Journal for Science & Engineering (Springer Science & Business Media B.V. ), 2024, Vol 49, Issue 6, p8311
- ISSN
2193-567X
- Publication type
Article
- DOI
10.1007/s13369-024-08866-1