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- Title
Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation.
- Authors
Ramasawmy, Rajiv; Rogers, Toby; Alcantar, Miguel A.; McGuirt, Delaney R.; Khan, Jaffar M.; Kellman, Peter; Xue, Hui; Faranesh, Anthony Z.; Campbell-Washburn, Adrienne E.; Lederman, Robert J.; Herzka, Daniel A.
- Abstract
Background: The hallmark of heart failure is increased blood volume. Quantitative blood volume measures are not conveniently available and are not tested in heart failure management. We assess ferumoxytol, a marketed parenteral iron supplement having a long intravascular half-life, to measure the blood volume with cardiovascular magnetic resonance (CMR). Methods: Swine were administered 0.7 mg/kg ferumoxytol and blood pool T1 was measured repeatedly for an hour to characterize contrast agent extraction and subsequent effect on Vblood estimates. We compared CMR blood volume with a standard carbon monoxide rebreathing method. We then evaluated three abbreviated acquisition protocols for bias and precision. Results: Mean plasma volume estimated by ferumoxytol was 61.9 ± 4.3 ml/kg. After adjustment for hematocrit the resultant mean blood volume was 88.1 ± 9.4 ml/kg, which agreed with carbon monoxide measures (91.1 ± 18.9 ml/kg). Repeated measurements yielded a coefficient of variation of 6.9%, and Bland-Altman repeatability coefficient of 14%. The blood volume estimates with abbreviated protocols yielded small biases (mean differences between 0.01–0.06 L) and strong correlations (r2 between 0.97–0.99) to the reference values indicating clinical feasibility. Conclusions: In this swine model, ferumoxytol CMR accurately measures plasma volume, and with correction for hematocrit, blood volume. Abbreviated protocols can be added to diagnostic CMR examination for heart failure within 8 min.
- Subjects
ANIMAL experimentation; BLOOD plasma; BLOOD volume; CARBON monoxide; CARDIOVASCULAR disease diagnosis; DIETARY supplements; HEMATOCRIT; IRON compounds; MAGNETIC resonance imaging; MEDICAL protocols; REFERENCE values; SWINE; CONTRAST media; BLOOD volume determination
- Publication
Journal of Cardiovascular Magnetic Resonance (BioMed Central), 2018, Vol 20, Issue 1, pN.PAG
- ISSN
1532-429X
- Publication type
Article
- DOI
10.1186/s12968-018-0486-3