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- Title
The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.
- Authors
Orlow, Irene; Shi, Yang; Kanetsky, Peter A.; Thomas, Nancy E.; Luo, Li; Corrales‐Guerrero, Sergio; Cust, Anne E.; Sacchetto, Lidia; Zanetti, Roberto; Rosso, Stefano; Armstrong, Bruce K.; Dwyer, Terence; Venn, Alison; Gallagher, Richard P.; Gruber, Stephen B.; Marrett, Loraine D.; Anton‐Culver, Hoda; Busam, Klaus; Begg, Colin B.; Berwick, Marianne
- Abstract
Summary: Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (<italic>VDR</italic>) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′‐end haplotype were significant (<italic>p</italic> < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between <italic>VDR</italic> and melanoma‐specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.
- Subjects
VITAMIN D receptors; SINGLE nucleotide polymorphisms; PHYSIOLOGICAL effects of solar radiation; MELANOMA; HAPLOTYPES; CANCER risk factors
- Publication
Pigment Cell & Melanoma Research, 2018, Vol 31, Issue 2, p287
- ISSN
1755-1471
- Publication type
Article
- DOI
10.1111/pcmr.12653