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- Title
Alteraciones en la perfusión cerebral en pacientes con esclerosis sistémica y deterioro cognitivo.
- Authors
Moreno-Gutiérrez, Juan; Vera-Lastra, Olga Lidia; Coria-Moctezuma, Luis Alonso; del Pilar Cruz-Domínguez, María
- Abstract
Introduction: Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis, immunological and vascular abnormalities. Cerebral hypoperfusion can be caused by cerebral ischemia. Cognitive impairment (CI) are a major cause of morbidity in SSc The aim of this study is to estimate the frequency of alterations in cerebral perfusion (CP) in SSc patients with CI. Methods: We studied 88 patients with SSc. The Montreal Test (MT) was given to all patients to evaluate CI. To 15 patients with CI and without systemic hypertension, diabetes mellitus, cerebrovascular disease, vasculitis, hypothyroidism, depression, and drugs that interfere with the cognitive assessment, the PC was measured by cerebral gammagram (CG). Results: Of the 88 patients with ES, 58 had CI by MT. A decrease in CP was observed in following lobes: frontal in 9 of 15 patients, temporal in 7 of 15, and parietal in 3 of 15. Concordance between MT and CG was 60 % for the frontal, 46 % for the temporal and parietal 13 %. Conclusions: The CI is common in SSc. A decrease in CP was more frequent in the frontal lobe, predominating in older patients and with longer duration of SSc.
- Subjects
SYSTEMIC scleroderma; COGNITION disorder risk factors; CEREBRAL ischemia; BLOOD flow; DISEASE risk factors
- Publication
Revista Medica del IMSS, 2015, Vol 53, pS42
- ISSN
0443-5117
- Publication type
Case Study