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- Title
Agent Orange Reviewed: Potential Role in Peripheral Neuropathy and Neurodegeneration.
- Authors
de la Monte, S.; Goel, A.
- Abstract
Agent Orange, a dioxin-containing toxin, was used as a herbicide during the Vietnam War Agent Orange exposure was initially linked to congenital disabilities among Vietnamese civilians residing near aerially sprayed regions Years later, returning South Korean and United States (US) Veterans exposed to Agent Orange exhibited increased rates of malignancy, cardiovascular disease, diabetes and congenital disabilities in their offspring Growing evidence that herbicides and pesticides contribute to chronic diseases, including neurodegeneration, raises concern that Agent Orange exposures may have increased the risk for later development of peripheral or central nervous system (CNS) degeneration This article reviews published data on the main systemic effects and the prevalence rates, relative risks, characteristics and correlates of Agent Orange-associated peripheral neuropathy and CNS dementia-associated diseases The critical findings demonstrated that relatively high levels of Agent Orange exposure increased the risk of developing peripheral neuropathy, either alone or as a cofactor complication of diabetes mellitus, and likely contributed to the pathogenesis of CNS degenerative diseases, including Alzheimer's, Parkinson's and vascular dementias Given the protracted interval between Agent Orange exposure and disease emergence, additional research is needed to identify mechanistic correlations of related neurological disorders, including lifestyle cofactors.
- Subjects
DEMENTIA risk factors; RISK factors of neurodegeneration; ALZHEIMER'S disease risk factors; CENTRAL nervous system diseases; VASCULAR dementia; NEUROLOGICAL disorders; PERIPHERAL nervous system; PARKINSON'S disease; HERBICIDES; ENVIRONMENTAL exposure; NEURODEGENERATION; DISEASE risk factors
- Publication
Journal of Military & Veterans' Health, 2022, Vol 30, Issue 2, p17
- ISSN
1835-1271
- Publication type
Article