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- Title
Association of Amine-Receptor DNA Sequence Variants with Associative Learning in the Honeybee.
- Authors
Lagisz, Malgorzata; Mercer, Alison; Mouzon, Charlotte; Santos, Luana; Nakagawa, Shinichi
- Abstract
Octopamine- and dopamine-based neuromodulatory systems play a critical role in learning and learning-related behaviour in insects. To further our understanding of these systems and resulting phenotypes, we quantified DNA sequence variations at six loci coding octopamine-and dopamine-receptors and their association with aversive and appetitive learning traits in a population of honeybees. We identified 79 polymorphic sequence markers (mostly SNPs and a few insertions/deletions) located within or close to six candidate genes. Intriguingly, we found that levels of sequence variation in the protein-coding regions studied were low, indicating that sequence variation in the coding regions of receptor genes critical to learning and memory is strongly selected against. Non-coding and upstream regions of the same genes, however, were less conserved and sequence variations in these regions were weakly associated with between-individual differences in learning-related traits. While these associations do not directly imply a specific molecular mechanism, they suggest that the cross-talk between dopamine and octopamine signalling pathways may influence olfactory learning and memory in the honeybee.
- Subjects
NUCLEOTIDE sequence; AMINE analysis; ASSOCIATIVE learning; HONEYBEE behavior; OCTOPAMINE; DOPAMINE
- Publication
Behavior Genetics, 2016, Vol 46, Issue 2, p242
- ISSN
0001-8244
- Publication type
Article
- DOI
10.1007/s10519-015-9749-z