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- Title
Improved Utilization of Serial Testing Without Increased Admissions after Implementation of High-Sensitivity Troponin I: a Controlled Retrospective Cohort Study.
- Authors
Warren, Laura; Fischer, Brett G.; Shemesh, Amos; Scofi, Jean; Pandya, Nekee; Kim, Robert J.; Andy, Caroline; Rand, Sophie; Yee, Jim; Semple, Stacia; Chadburn, Amy; Yang, He S.; Steel, Peter A. D.; Zhao, Zhen
- Abstract
Background: Guidelines recommend high-sensitivity cardiac troponin (hs-cTn) for diagnosis of myocardial infarction. Use of hs-cTn is increasing across the U.S., but questions remain regarding clinical and operational impact. Prior studies have had methodologic limitations and yielded conflicting results. Objective: To evaluate the impact of transitioning from conventional cardiac troponin (cTn) to hs-cTn on test and resource utilization, operational efficiency, and patient safety. Design: Retrospective cohort study in two New York City hospitals during the months before and after transition from conventional cTn to hs-cTn at Hospital 1. Hospital 2 served as a control. Participants: Consecutive emergency department (ED) patients with at least one cTn test resulted. Intervention: Multifaceted hs-cTn intervention bundle, including a 0/2-h diagnostic algorithm for non-ST-elevation myocardial infarction, an educational bundle, enhancements to the electronic medical record, and nursing interventions to facilitate timed sample collection. Main Measures: Primary outcomes included serial cTn test utilization, probability of hospital admission, ED length of stay (LOS), and among discharged patients, probability of ED revisit within 72 h resulting in hospital admission. Multivariable regression models adjusted for age, sex, temporal trends, and interhospital differences. Key Results: The intervention was associated with increased use of serial cTn testing (adjusted risk difference: 48 percentage points, 95% CI: 45–50, P < 0.001) and ED LOS (adjusted geometric mean difference: 50 min, 95% CI: 50–51, P < 0.001). There was no significant association between the intervention and probability of admission (adjusted relative risk [aRR]: 0.99, 95% CI: 0.89–1.1, P = 0.81) or probability of ED revisit within 72 h resulting in admission (aRR: 1.1, 95% CI: 0.44–2.9, P = 0.81). Conclusions: Implementation of a hs-cTn intervention bundle was associated with an improvement in serial cTn testing, a neutral effect on probability of hospital admission, and a modest increase in ED LOS.
- Subjects
NEW York (N.Y.); TROPONIN I; NON-ST elevated myocardial infarction; MYOCARDIAL infarction; ELECTRONIC health records; COHORT analysis
- Publication
JGIM: Journal of General Internal Medicine, 2024, Vol 39, Issue 5, p739
- ISSN
0884-8734
- Publication type
Article
- DOI
10.1007/s11606-023-08535-3