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- Title
Trends in Self-reported Prediabetes and Metformin Use in the USA: NHANES 2005-2014.
- Authors
Liu, Caroline; Foti, Kathryn; Grams, Morgan E.; Shin, Jung-Im; Selvin, Elizabeth
- Abstract
<bold>Background: </bold>The American Diabetes Association (ADA) recommends that treatment with metformin be considered for prevention of type 2 diabetes in persons with prediabetes. However, metformin use outside the setting of diagnosed diabetes in US adults is not well characterized.<bold>Objective: </bold>To examine trends in self-reported prediabetes and treatment with metformin. We also compared characteristics of adults self-reported prediabetes who were vs. were not taking metformin.<bold>Design: </bold>Cross-sectional analysis.<bold>Participants: </bold>Adults ≥ 20 years of age who participated in the 2005-2014 National Health and Nutrition and Examination Survey (NHANES), n = 28,461.<bold>Approach: </bold>We characterized trends in self-reported prediabetes and metformin use in this population. We used multiple logistic regression models to identify predictors of metformin use among adults with self-reported prediabetes. All analyses accounted for the weighted complex survey design to generate nationally representative estimates.<bold>Key Results: </bold>The prevalence of self-reported prediabetes increased from 5.1% in 2005-2006 to 7.4% in 2013-2014 (P-for-trend < 0.001). In persons with self-reported prediabetes, metformin use increased, from 2.4 to 8.3% (P-for-trend = 0.013). Adults who were taking metformin were more likely to be obese and to report trying to lose weight in the past year.<bold>Conclusions: </bold>Self-reported prediabetes has increased in the past decade. Metformin use in the setting of prediabetes has also increased but remains relatively uncommon at 8% in adults who self-report prediabetes, despite current clinical recommendations.
- Subjects
PREDIABETIC state; HEALTH &; Nutrition Examination Survey; METFORMIN; TYPE 2 diabetes
- Publication
JGIM: Journal of General Internal Medicine, 2020, Vol 35, Issue 1, p95
- ISSN
0884-8734
- Publication type
journal article
- DOI
10.1007/s11606-019-05398-5