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- Title
Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview.
- Authors
de Bem, Andreza Fabro; Krolow, Rachel; Farias, Hémelin Resende; de Rezende, Victória Linden; Gelain, Daniel Pens; Moreira, José Cláudio Fonseca; Duarte, João Miguel das Neves; de Oliveira, Jade
- Abstract
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer's and Parkinson's disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer's and Parkinson's disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer's and Parkinson's disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.
- Subjects
METABOLIC disorders; NEURODEGENERATION; METABOLIC models; BLOOD-brain barrier; PARKINSON'S disease; ANIMAL models in research
- Publication
Frontiers in Neuroscience, 2021, Vol 14, pN.PAG
- ISSN
1662-4548
- Publication type
Article
- DOI
10.3389/fnins.2020.604150