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- Title
Neuropsychiatric Disorders in Parkinson's Disease: What Do We Know About the Role of Dopaminergic and Non-dopaminergic Systems?
- Authors
Dujardin, Kathy; Sgambato, Véronique
- Abstract
Besides the hallmark motor symptoms (rest tremor, hypokinesia, rigidity, and postural instability), patients with Parkinson's disease (PD) have non-motor symptoms, namely neuropsychiatric disorders. They are frequent and may influence the other symptoms of the disease. They have also a negative impact on the quality of life of patients and their caregivers. In this article, we will describe the clinical manifestations of the main PD-related behavioral disorders (depression, anxiety disorders, apathy, psychosis, and impulse control disorders). We will also provide an overview of the clinical and preclinical literature regarding the underlying mechanisms with a focus on the role of the dopaminergic and non-dopaminergic systems.
- Subjects
PARKINSON'S disease; NEUROBEHAVIORAL disorders; APATHY; TREMOR; IMPULSE control disorders; SYMPTOMS; ANXIETY disorders; HYPOKINESIA
- Publication
Frontiers in Neuroscience, 2020, Vol 14, p1
- ISSN
1662-4548
- Publication type
Article
- DOI
10.3389/fnins.2020.00025