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- Title
Left Ventricular Mass Index as Potential Surrogate of Muscularity in Patients With Systemic Sclerosis Without Cardiovascular Disease.
- Authors
Molfino, Alessio; Gasperini, Maria Ludovica; Gigante, Antonietta; Rosato, Edoardo; Muscaritoli, Maurizio
- Abstract
Background: Systemic sclerosis (SSc) may be associated with protein‐energy malnutrition. It was demonstrated that left ventricular mass (LVM) reflected poor nutrition status in SSc patients, and no data are available on LVM as a surrogate measure of muscularity. We aimed to evaluate, in SSc patients, the relationship between muscle mass and LVM as a novel indicator of muscularity in this setting. Methods: SSc patients and healthy controls (HCs) were considered and underwent echocardiography to assess LVM and LVM index (LVMI). Body composition, including fat‐free mass index (FFMI), phase angle (PhA), and body cell mass index (BCMI), was analyzed by multifrequency bioelectrical impedance analysis. Results: Sixty‐four SSc patients (aged 51 ± 13 years) and 30 HCs (aged 46 ± 13 years) were enrolled. BCMI and PhA were lower in SSc patients compared with HCs (P <.001). LVM and LVMI were not different between SSc patients and HCs (P =.068, P =.14, respectively). In SSc patients, a significant correlation was shown between LVMI and FFMI (τ = 0.192, P =.026); in multiple regression analysis, FFMI was significantly associated with the Malnutrition Universal Screening Tool (P <.0001), LVMI (P =.01), and disease severity scale (P =.02). Conclusion: Changes in body composition were present in SSc patients, particularly in terms of BMCI and PhA. A correlation between LVMI and FFMI as indexes of muscularity exists in this cohort, suggesting that cardiac mass might be used as a surrogate of nutrition status in this setting.
- Subjects
CARDIOVASCULAR diseases; SYSTEMIC scleroderma; PROTEIN-energy malnutrition; MULTIPLE regression analysis; BIOELECTRIC impedance
- Publication
JPEN Journal of Parenteral & Enteral Nutrition, 2021, Vol 45, Issue 6, p1302
- ISSN
0148-6071
- Publication type
Article
- DOI
10.1002/jpen.1999