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- Title
A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE).
- Authors
Raviele, Antonio; Giada, Franco; Menozzi, Carlo; Speca, Giancarlo; Orazi, Serafino; Gasparini, Gianni; Sutton, Richard; Brignole, Michele
- Abstract
Aims Recently, some studies revealed the efficacy of pacemaker implantation in decreasing recurrences in patients with vasovagal syncope. As these studies were not blinded or placebo-controlled, the benefits observed might have been due to a bias in the assessment of outcomes or to a placebo effect of the pacemaker. We performed a randomized, double-blind, placebo-controlled study in order to ascertain if pacing therapy reduces the risk of syncope relapse. Methods and results Twenty-nine patients (53±16 years; 19 women) with severe recurrent tilt-induced vasovagal syncope (median 12 syncopes in the lifetime) and 1 syncopal relapse after head-up tilt testing underwent implantation of a pacemaker, and were randomized to pacemaker ON or to pacemaker OFF. Conclusion Our data were unable to show a superiority of active pacing versus inactive pacing in preventing syncopal recurrence in patients with severe recurrent tilt-induced vasovagal syncope.
- Publication
European Heart Journal, 2004, Vol 25, Issue 19, p1741
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1016/j.ehj.2004.06.031