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- Title
YOGURT FORTIFIED WITH PURPLE ROSELLE EXTRACT AS PREVENTION OF DIOXIN INTOXICATION BASED ON MALONDIALDEHYDE LEVELS AND HISTOPATHOLOGY OF RATS (RATTUS NORVEGICUS) KIDNEY.
- Authors
Setianingrum, Ani; Francia, Allan Jeffrey; Kusumaningdyah, Dhanti; Widodo, Edwin; Noviatri, Aldila; Jeffrey Francia, Allan; Haskito, Ajeng Erika P.
- Abstract
Dioxin is one of the chemical compounds produced through the chemical industry's combustion process, can pollute the environment, and harms the health of living things. Exposure to dioxin that accumulates in the body can disrupt normal organ function, including the kidneys. This study aimed to determine the preventive effect of giving yogurt fortified with purple roselle extract on the conditions of dioxin intoxication based on the parameters of Malondialdehyde MDA levels and kidney histopathology. This study used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which has the highest toxic potential among other dioxins congeners. TCDD was diluted in corn oil. This study used white male rats (Rattus norvegicus), 30 animals were divided into 5 treatment groups (1) negative control without treatment, (2) positive control was given TCDD dose of 200 ng/kg b.wt./day, (3) P1 given TCDD 200 ng/kg b.wt./day and roselle yogurt concentration of 0.5% 1 ml, (4) P2 given TCDD 200 ng/kg b.wt./day and roselle yogurt 1% concentration 1 ml, (5) P3 were given TCDD 200 ng/kg b.wt./day and roselle yogurt with a concentration of 1.5% 1 ml. The treatment was given for 12 days, orally. The parameters gathered were MDA levels and kidney histopathological changes. MDA levels were analyzed quantitatively using ANOVA continued with the Tukey test for comparison of treatment (α = 5%). Histopathological changes were analyzed descriptively. This study concludes that yogurt fortification with purple rosella extract with a concentration of 0.5%, 1.0%, and 1.5% as prevention on dioxin intoxication has not been able to decrease MDA levels of rat kidney and to prevent the histopathological damage of kidney rats.
- Subjects
DIOXINS; RATTUS norvegicus; MALONDIALDEHYDE; YOGURT; ROSELLE; CORN oil; KIDNEYS; HISTOPATHOLOGY
- Publication
Veterinary Practitioner, 2020, Vol 21, p497
- ISSN
0972-4036
- Publication type
Article