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- Title
Therapeutic Applications of Octreotide in Pediatric Patients.
- Authors
Al-Hussaini, Abdulraham; Butzner, Decker
- Abstract
Background/Aim: We report our experience with the use of octreotide as primary or adjunctive therapy in children with various gastrointestinal disorders. Patients and Methods: A pharmacy database identified patients who received octreotide for gastrointestinal diseases. Indications for octreotide use, dosing, effectiveness, and adverse events were evaluated by chart review. Results: A total of 21 patients (12 males), aged 1 month to 13 years, were evaluated. Eleven received octreotide for massive gastrointestinal bleeding caused by portal hypertension-induced lesions (n=7), typhlitis (1), Meckel's diverticulum (1), and indefinite source (2). Blood transfusion requirements were reduced from 23±9 mL/kg (mean±SD) to 8±15 mL/kg (P<0.01). Four patients with pancreatic pseudocyst and/or ascites received octreotide over 14.0±5.7 days in 2 patients. In 3 children, pancreatic pseudocyst resolved in 12±2 days and pancreatic ascites resolved in 7 days in 2. Three patients with chylothorax received octreotide for 14±7 days with complete resolution in each. Two infants with chronic diarrhea received octreotide over 11±4.2 months. Stool output decreased from 85±21 mL/kg/day to 28±18 mL/kg/day, 3 months after initiation of octreotide. The child with dumping syndrome responded to octreotide in a week. Adverse events developed in 4 patients: Q-T interval prolongation and ventricular fibrillation, hyperglycemia, growth hormone deficiency, and hypertension. Conclusion: Octreotide provides a valuable addition to the therapeutic armamentum of the pediatric gastroenterologist for a wide variety of disorders. Serious adverse events may occur and patients must be closely monitored.
- Subjects
ALBERTA; ASCITES; BLOOD testing; BLOOD transfusion; CHEST X rays; CHYLOTHORAX; DATABASES; DIARRHEA; DUMPING syndrome; ELECTROCARDIOGRAPHY; GASTROINTESTINAL hemorrhage; GASTROINTESTINAL diseases; MEDICAL records; PANCREATIC cysts; OCTREOTIDE acetate; PATIENT monitoring; PORTAL hypertension; SOMATOSTATIN; EQUIPMENT &; supplies; RETROSPECTIVE studies; PHARMACODYNAMICS; CHILDREN; THERAPEUTICS
- Publication
Saudi Journal of Gastroenterology, 2012, Vol 18, Issue 2, p87
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.93807