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- Title
Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction.
- Authors
Jun-Kai Yan; Ke-Jun Zhou; Jian-Hu Huang; Qing-Qing Wu; Tian Zhang; Chao-Chen Wang; Wei Cai; Yan, Jun-Kai; Zhou, Ke-Jun; Huang, Jian-Hu; Wu, Qing-Qing; Zhang, Tian; Wang, Chao-Chen; Cai, Wei
- Abstract
Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal motility disorder with significant morbidity and mortality in pediatric patients. The diagnosis of CIPO is difficult, because it is clinically based on the symptoms and signs of bowel obstruction which are similar to the clinical manifestations of other gastrointestinal diseases like short bowel syndrome (SBS). Therefore, it is desirable to identify and establish new laboratory diagnostic markers for CIPO that are reliable and easily accessible. In our study we have identified the ratio of the urinary glutamine and glutamic acid as a promising biomarker for distinguishing suspected CIPO cases and simple SBS cases. The area under ROC curve was 0.83, at cutoff value = 7.04 with sensitivity of 65% and specificity of 92%.
- Subjects
GLUTAMINE; GLUTAMIC acid; URINALYSIS; BIOMARKERS; BOWEL obstructions; CHILDREN'S health; CHRONIC diseases
- Publication
Orphanet Journal of Rare Diseases, 2017, Vol 12, p1
- ISSN
1750-1172
- Publication type
letter
- DOI
10.1186/s13023-017-0615-3