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- Title
Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative.
- Authors
Lee, Jaeok; Chae, Song Wha; Ma, LianJi; Lim, So Yeon; Alnajjar, Sarah; Park Choo, Hea-Young; Lee, Hwa Jeong; Rhie, Sandy Jeong
- Abstract
P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs.
- Subjects
ACID derivatives; PACLITAXEL; FERULIC acid; DRUG derivatives; MULTIDRUG resistance; BIOAVAILABILITY
- Publication
Pharmaceutics, 2019, Vol 11, Issue 11, p593
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics11110593