We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Correlations between the Intensity of Histopathological Ubiquitin-Specific Protease 11 Staining and Progression of Prostate Cancer.
- Authors
Kim, Jae Heon; Yang, Hee Jo; Lee, Kwang Woo; Park, Jae Joon; Lee, Chang-Ho; Jeon, Youn Soo; Kim, Jae Ho; Park, Suyeon; Song, Su Jung; Lee, Ji-Hye; Moon, Ahrim; Kim, Yon Hee; Song, Yun Seob
- Abstract
Background: Ubiquitin-specific protease 11 (USP11), one of the principal phosphatase and tensin homolog (PTEN) deubiquitinases, can reserve PTEN polyubiquitination to maintain PTEN protein integrity and inhibit PI3K/AKT pathway activation. The aim of the current study was to investigate the associations between immunohistochemical USP11 staining intensities and prognostic indicators in individuals with prostate cancer. Methods: Tissue microarrays (TMAs) were performed for human prostate cancer and normal tissue (control) samples. Data on patient's age, Gleason score, plasma prostate-specific antigen (PSA) titer, disease stage, and presence of seminal vesicles, lymph nodes, and surgical margin involvement were collected. A pathologist who was blinded to the clinical outcome data scored the TMA for USP11 staining intensity as either positive or negative. Results: Cancerous tissues exhibited lower USP11 staining intensity, whereas the neighboring benign peri-tumoral tissues showed higher USP11 staining intensity. The degree of USP11 staining intensity was lower in patients with a higher PSA titer, higher Gleason score, or more advanced disease stage. Patients who showed positive USP11 staining were more likely to have more optimal clinical and biochemical recurrence-free survival statistics. Conclusions: USP11 staining intensity in patients with prostate cancer is negatively associated with several prognostic factors such as an elevated PSA titer and a high Gleason score. It also reflects both biochemical and clinical recurrence-free survival in such patients. Thus, USP11 staining is a valuable prognostic factor in patients with prostate cancer.
- Subjects
DEUBIQUITINATING enzymes; PROSTATE cancer prognosis; PROSTATE cancer; PTEN protein; PROSTATE cancer patients
- Publication
Pharmaceuticals (14248247), 2023, Vol 16, Issue 12, p1703
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph16121703