We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study.
- Authors
Blank, M M; Wentzensen, N; Murphy, M A; Hollenbeck, A; Park, Y
- Abstract
Background:Fat intake has been postulated to increase risk of ovarian cancer, but previous studies have reported inconsistent results.Methods:The NIH-AARP Diet and Health Study, a large prospective cohort, assessed diet using a food frequency questionnaire at baseline in 1995-1996. During an average of 9 years of follow-up, 695 ovarian cancer cases were ascertained through the state cancer registry database. The relative risks (RRs) and 95% confidence interval (CI) were estimated using a Cox proportional hazard model.Results:Women in the highest vs the lowest quintile of total fat intake had a 28% increased risk of ovarian cancer (RRQ5 vs Q1=1.28, 95% CI: 1.01-1.63). Fat intake from animal sources (RRQ5 vs Q1=1.30; 95% CI: 1.02-1.66), but not from plant sources, was positively associated with ovarian cancer risk. Saturated and monounsaturated fat intakes were not related to risk of ovarian cancer, but polyunsaturated fat intake showed a weak positive association. The association between total fat intake and ovarian cancer was stronger in women who were nulliparous or never used oral contraceptives.Conclusion:Fat intake, especially from animal sources, was related to an increased risk of ovarian cancer. The association may be modified by parity and oral contraceptive use, which warrants further investigation.
- Subjects
FAT; OVARIAN cancer; QUESTIONNAIRES; CONFIDENCE intervals; PROPORTIONAL hazards models; DISEASES in women; PHYSIOLOGICAL effects of oral contraceptives; COHORT analysis; DISEASE risk factors
- Publication
British Journal of Cancer, 2012, Vol 106, Issue 3, p596
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/bjc.2011.572