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- Title
Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma.
- Authors
Jing-Jing Song; Si-Jia Zhao; Juan Fang; Da Ma; Xiang-Qi Liu; Xiao-Bing Chen; Yun Wang; Bin Cheng; Zhi Wang; Song, Jing-Jing; Zhao, Si-Jia; Fang, Juan; Ma, Da; Liu, Xiang-Qi; Chen, Xiao-Bing; Wang, Yun; Cheng, Bin; Wang, Zhi
- Abstract
<bold>Background: </bold>Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC).<bold>Methods: </bold>Foxp3 expression was examined using immunohistochemistry (IHC) in paraffin-embedded tissue samples from 273 OSCC patients. Statistical analysis was performed to evaluate the associations between Foxp3 expression, the clinicopathologic characteristics and prognostic factors in OSCC.<bold>Results: </bold>Foxp3 protein expression was significantly associated with lymph node metastasis (P <0.01). Both univariate and multivariate analyses revealed that Foxp3 was an independent factor for both 5 years overall survival (OS) and relapse-free survival (RFS) (both P <0.01). Patients with Foxp3 overexpression had shorter OS and RFS.<bold>Conclusions: </bold>Our results determined that elevated Foxp3 protein expression was a predictive factor of outcome in OSCC and could act as a promising therapeutic target.
- Subjects
FORKHEAD transcription factors; PROTEIN expression; ORAL cancer; SQUAMOUS cell carcinoma; T cells; MULTIVARIATE analysis; PROGNOSIS
- Publication
BMC Cancer, 2016, Vol 16, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-016-2419-6