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- Title
Lost in translation.
- Authors
Julier, Cécile
- Abstract
Translation initiation is a tightly regulated process, central to cell function, and proteins involved in this process and its regulation are highly conserved throughout evolution. New results show that mutations in genes encoding subunits of the ubiquitously expressed elF2B translation initiation factor are responsible for a rare neurological disorder in humans—leukoencephalopathy with vanishing white matter (VWM). The elF2/elF2B complex has a key role in the response to a variety of stress conditions. Notably, mutations affecting other proteins of this complex or regulatory kinases cause distinct disorders.
- Subjects
GENETIC translation; GENETIC mutation
- Publication
Nature Genetics, 2001, Vol 29, Issue 4, p358
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1201-358