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- Title
Detection of an early HIV-1 infection by HIV RNA testing in an Italian blood donor during the preseroconversion window period.
- Authors
Aprili G; Gandini G; Piccoli P; Bressan F; De Gironcoli M; Mazzi R; Parisi SG; Gessoni G; Marchiori G; Franchini M; Aprili, Giuseppe; Gandini, Giorgio; Piccoli, Pierluigi; Bressan, Fausto; De Gironcoli, Marzia; Mazzi, Romualdo; Parisi, Saverio G; Gessoni, Gianluca; Marchiori, Giorgio; Franchini, Massimo
- Abstract
<bold>Background: </bold>The implementation of NAT technologies for HIV screening has further reduced the diagnostic window in recent HIV infection. There is still a debate regarding the cost effectiveness of genomic screening of blood donations for transfusion-transmitted viruses (HBV, HCV, HIV).<bold>Study Design and Methods: </bold>Since October 2001, at the Transfusion Service of Verona, single-donation NAT testing for HCV and HIV-1 (Procleix TMA HIV-1/HCV Assay) of all blood donations has been performed.<bold>Case Report: </bold>A case of acute HIV-1 infection detected by HIV NAT in a repeat blood donor who donated during the preseroconversion window period is reported. All blood components donated were discarded, and the donor started antiretroviral therapy 2 weeks after blood donation. HIV-1 p24 antigen was still negative 10 days after the HIV-1 RNA-positive blood donation. Seroconversion was documented by Day 41 after donation.<bold>Conclusion: </bold>This case report testifies that HIV NAT screening of blood donation is effective in preventing the transmission of HIV infection through blood components.
- Publication
Transfusion, 2003, Vol 43, Issue 7, p848
- ISSN
0041-1132
- Publication type
journal article