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- Title
Contrast Volume-to-Creatinine Clearance Ratio Predicts the Risk of Contrast-Induced Nephropathy After Percutaneous Coronary Intervention in Patients With Reduced Ejection Fraction.
- Authors
Liu, Yong; Chen, Shi-Qun; Duan, Chong-Yang; Tan, Ning; Chen, Ji-Yan; Zhou, Ying-Ling; Chen, Ping-Yan; Huang, Shui-Jin; Liu, Xiao-Qi
- Abstract
We determined a relatively safe contrast media volume-to-creatinine clearance (V/CrCl) cutoff value to avoid contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients (n = 111) with reduced ejection fraction (<40%). Improved prediction of CIN in these patients would be useful. Multivariate regression models were used to evaluate whether V/CrCl is an independent risk factor for CIN. Nine (8.1%) patients developed CIN. The V/CrCl was significantly (P = .023) higher in patients with CIN than in those without. The incidence of CIN in patients with the highest tertile of V/CrCl was significantly higher than the middle and lowest tertiles (18.4% vs 2.7% and 2.8%; P = .013). After adjusting for other potential risk factors, a V/CrCl ≥3.87 remained significantly associated with risk of CIN. A V/CrCl <3.87 might be valuable in predicting the risk of CIN in patients with reduced ejection fraction undergoing PCI.
- Subjects
BIOTRANSFORMATION (Metabolism); CARDIAC output; CHI-squared test; CONFIDENCE intervals; FISHER exact test; HEART beat; KIDNEY diseases; LONGITUDINAL method; SCIENTIFIC observation; RESEARCH funding; STATISTICAL hypothesis testing; STATISTICS; T-test (Statistics); TRANSLUMINAL angioplasty; DATA analysis; CONTRAST media; PROPORTIONAL hazards models; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; LOG-rank test; ODDS ratio
- Publication
Angiology, 2015, Vol 66, Issue 7, p625
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319714548442