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- Title
Angiogenin and Hemoxygenase in Pregnancy: Influence of Hypertension.
- Authors
Karthikeyan, Velore J.; Lip, Gregory Y. H.; Baghdadi, Sabah; Lane, Deirdre A.; Beevers, D. Gareth; Blann, Andrew D.
- Abstract
The pathophysiology of hypertension and preeclampsia involves angiogenesis and endothelial damage/dysfunction, as shown by abnormal growth factors (vascular endothelial growth factor [VEGF], and its receptor sFlt-1) and von Willebrand factor (vWf) in the plasma. Angiogenin and hemoxygenase are abnormal in hypertension and angiogenesis but data on pregnancy are scant. We hypothesized altered angiogenin and hemoxygenase in 38 hypertensive pregnant women (HTPW) compared to 38 normotensive pregnant women (NTPW) and 50 nonpregnant controls (NonPCs). Plasma markers were measured by enzyme-linked immunosorbent assay (ELISA). Hypertensive pregnant women had lower VEGF than NonPCs (P < .01), vWf was raised in both pregnant groups (P < .01), but sFlt-1 was no different. Both angiogenin and hemoxygenase were lower in NTPW compared to NonPCs (both p<0.02). In both pregnancy groups, angiogenin correlated with vWf (r > .33, P < .05), but in NonPCs this was not significant (r = .13, P = .367). These changes may reflect differences in endothelial cell physiology and pathology in the hypertension in pregnancy.
- Subjects
ANALYSIS of variance; BLOOD coagulation factors; BLOOD pressure; ENZYME-linked immunosorbent assay; ESTERASES; GROWTH factors; HYPERTENSION; OXIDOREDUCTASES; PREECLAMPSIA; STATISTICS; T-test (Statistics); DATA analysis; VASCULAR endothelial growth factors; DESCRIPTIVE statistics; PREGNANCY
- Publication
Angiology, 2012, Vol 63, Issue 3, p194
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319711410308