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- Title
Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line.
- Authors
Jubie, Selvaraj; Dhanabal, Palanisamy; Azam, Mohammed Afzal; Muruganantham, Nithyanantham; Kalirajan, Rajagopal; Elango, Kannan
- Abstract
Background: Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity. Methods: Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3, 4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, ¹H NMR, 13C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro. Results: Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.
- Subjects
LINOLENIC acids; SPIRULINA platensis; SATURATED fatty acids; STEARIC acid; LUNG cancer
- Publication
Lipids in Health & Disease, 2013, Vol 12, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/1476-511X-12-45