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- Title
Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis.
- Authors
Guiddir, Tamazoust; Deghmane, Ala-Eddine; Giorgini, Dario; Muhamed-Kheir Taha
- Abstract
Background Early differential diagnosis between acute bacterial and viral meningitis is problematic. We aimed to investigate whether the detection of lipocalin 2, a protein of the acute innate immunity response, may be used as a marker for acute bacterial meningitis. Methods Transgenic mice expressing the human transferrin were infected by intraperitoneal route and were imaged. Cerebrospinal fluid (CSF) was sampled up to 48hours post- infection to measure lipocalin 2. We also tested a collection of 90 and 44 human CSF with confirmed acute bacterial or acute viral meningitis respectively. Results Lipocalin 2 was detected after 5 h in CSF during experimental infection in mice. Lipocalin 2 levels were significantly higher (p < 0.0001) in patients with confirmed acute bacterial meningitis (mean 125 pg/mL, range 106-145 pg/mL) than in patients with acute viral meningitis (mean 2 pg/mL, range 0-6 pg/mL) with a sensitivity of 81%, a specificity of 93%, a positive predictive value of 96% and a negative predictive value of 71% in diagnosing acute bacterial meningitis. Conclusions Increased levels of lipocalin 2 in cerebrospinal fluid may discriminate between acute bacterial and viral meningitis in patients with clinical syndrome of meningitis.
- Subjects
LIPOCALIN-2; CEREBROSPINAL fluid; BACTERIAL meningitis; DIFFERENTIAL diagnosis; HAEMOPHILUS influenzae; NEISSERIA meningitidis; STREPTOCOCCUS pneumoniae
- Publication
BMC Infectious Diseases, 2014, Vol 14, Issue 1, p1
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/1471-2334-14-276