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- Title
Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development.
- Authors
Peng Tan; Lian He; Changsheng Xing; Jingrong Mao; Xiao Yu; Motao Zhu; Lixia Diao; Leng Han; Yubin Zhou; You, James M.; Wang, Helen Y.; Rong-Fu Wang; Tan, Peng; He, Lian; Xing, Changsheng; Mao, Jingrong; Yu, Xiao; Zhu, Motao; Diao, Lixia; Han, Leng
- Abstract
Beclin 1 (Becn1) is a key molecule in the autophagy pathway and has been implicated in cancer development. Due to the embryonic lethality of homozygous Becn1-deficient mice, the precise mechanisms and cell type-specific roles of Becn1 in regulating inflammation and cancer immunity remain elusive. Here, we report that myeloid-deficient Becn1 (Becn1ΔM) mice developed neutrophilia, were hypersusceptible to LPS-induced septic shock, and had a high risk of developing spontaneous precursor B cell (pre-B cell) lymphoma with elevated expression of immunosuppressive molecules programmed death ligand 1 (PD-L1) and IL-10. Becn1 deficiency resulted in the stabilization of MEKK3 and aberrant p38 activation in neutrophils, and mediated neutrophil-B cell interaction through Cxcl9/Cxcr3 chemotaxis. Neutrophil-B cell interplay further led to the activation of IL-21/STAT3/IRF1 and CD40L/ERK signaling and PD-L1 expression; therefore, it suppressed CD8+ T cell function. Ablation of p38 in Becn1ΔM mice prevented neutrophil inflammation and B cell tumorigenesis. Importantly, the low expression of Becn1 in human neutrophils was significantly correlated with the PD-L1 levels in pre-B acute lymphoblastic lymphoma (ALL) patients. Our findings have identified myeloid Becn1 as a key regulator of cancer immunity and therapeutic target for pre-B cell lymphomas.
- Subjects
B cells; SEPTIC shock; CELL physiology; T cells; NEUTROPHILS
- Publication
Journal of Clinical Investigation, 2019, Vol 129, Issue 12, p5261
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI127721