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- Title
Assessing the Virologic Impact of Archived Resistance in the Dolutegravir/Lamivudine 2-Drug Regimen HIV-1 Switch Study TANGO through Week 144.
- Authors
Wang, Ruolan; Wright, Jonathan; Saggu, Parminder; Ait-Khaled, Mounir; Moodley, Riya; Parry, Chris M.; Lutz, Thomas; Podzamczer, Daniel; Moore, Richard; Górgolas Hernández-Mora, Miguel; Kinder, Clifford; Wynne, Brian; van Wyk, Jean; Underwood, Mark
- Abstract
The TANGO study (ClinicalTrials.gov, NCT03446573) demonstrated that switching to dolutegravir/lamivudine (DTG/3TC) was non-inferior to continuing tenofovir alafenamide-based regimens (TBR) through week 144. Retrospective baseline proviral DNA genotypes were performed for 734 participants (post-hoc analysis) to assess the impact of archived, pre-existing drug resistance on 144-week virologic outcomes by last on-treatment viral load (VL) and Snapshot. A total of 320 (86%) participants on DTG/3TC and 318 (85%) on TBR had both proviral genotype data and ≥1 on-treatment post-baseline VL results and were defined as the proviral DNA resistance analysis population. Archived International AIDS Society–USA major nucleoside reverse transcriptase inhibitor, non-nucleoside reverse transcriptase inhibitor, protease inhibitor, and integrase strand transfer inhibitor resistance-associated mutations (RAMs) were observed in 42 (7%), 90 (14%), 42 (7%), and 11 (2%) participants, respectively, across both groups; 469 (74%) had no major RAMs at baseline. M184V/I (1%), K65N/R (<1%), and thymidine analogue mutations (2%) were infrequent. Through week 144, >99% of participants on DTG/3TC and 99% on TBR were virologically suppressed (last on-treatment VL <50 copies/mL) regardless of the presence of major RAMs. Results from the sensitivity analysis by Snapshot were consistent with the last available on-treatment VL. In TANGO, archived, pre-existing major RAMs did not impact virologic outcomes through week 144.
- Subjects
LAMIVUDINE; RALTEGRAVIR; NUCLEOSIDE reverse transcriptase inhibitors; NON-nucleoside reverse transcriptase inhibitors; DOLUTEGRAVIR; HIV; DNA analysis
- Publication
Viruses (1999-4915), 2023, Vol 15, Issue 6, p1350
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v15061350