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- Title
Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors.
- Authors
Girolimetti, Giulia; De Iaco, Pierandrea; Procaccini, Martina; Panzacchi, Riccardo; Kurelac, Ivana; Amato, Laura Benedetta; Dondi, Giulia; Caprara, Giacomo; Ceccarelli, Claudio; Santini, Donatella; Porcelli, Anna Maria; Perrone, Anna Myriam; Gasparre, Giuseppe
- Abstract
Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are defined as invasive when cell proliferation invades the underlying tissue (peritoneal surface, omentum and intestinal wall), or noninvasive. It is still unknown if these implants are metastatic spread from the primary ovarian mass or a neoplastic transformation de novo of the peritoneal surface. Mitochondrial DNA sequencing was performed to assess clonality in eight patients presenting both borderline ovarian tumors and implants. In 37.5% of the cases, the same mitochondrial DNA mutation was present in both borderline ovarian tumors and the peritoneal implant, being this evidence that implants may arise as a consequence of a spread from a single ovarian site.
- Subjects
MITOCHONDRIAL DNA abnormalities; OVARIAN tumors; NUCLEOTIDE sequencing; STROMAL cells; CELL proliferation; PERITONEAL macrophages
- Publication
Molecular Cancer, 2017, Vol 16, p1
- ISSN
1476-4598
- Publication type
Article
- DOI
10.1186/s12943-017-0614-y