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- Title
The Generation of Diazo Compounds in Continuous‐Flow.
- Authors
Hock, Katharina J.; Koenigs, Rene M.
- Abstract
Abstract: Toxic, cancerogenic and explosive—these attributes are typically associated with diazo compounds. Nonetheless, diazo compounds are nowadays a highly demanded class of reagents for organic synthesis, yet the concerns with regards to safe and scalable transformations of these compounds are still exceptionally high. Lately, the research area of the continuous‐flow synthesis of diazo compounds attracted significant interest and a whole variety of protocols for their “on‐demand” preparation have been realized to date. This concept article focuses on the recent developments using continuous‐flow technologies to access diazo compounds; thus minimizing risks and hazards when working with this particular class of compounds. In this article we discuss these concepts and highlight different pre‐requisites to access and to perform downstream functionalization reaction.
- Subjects
DIAZO compounds; ORGANIC synthesis; DIAZOTIZATION; ENANTIOSELECTIVE catalysis; NITROSO compounds
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 42, p10571
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201800136