We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Developmental drift as a mechanism for aging: lessons from nematodes.
- Authors
Lezzerini, Marco; Smith, Reuben L.; Budovskaya, Yelena
- Abstract
Aging is a universal biological process that afflicts every creature on this planet. To date, we have a very poor understanding of what actually causes this degeneration. A commonly held view is that aging is the result of damage accumulation over a lifetime. However, research has shown that aging is not only the result of wear and tear in the organism, but also of genetic programs involved in organismal development that go awry as selective pressure is released. This review focuses on Wnt signalling pathways and discusses how these genetic programs orchestrate changes in the organism that could cause aging.
- Publication
Biogerontology, 2013, Vol 14, Issue 6, p693
- ISSN
1389-5729
- Publication type
Letter
- DOI
10.1007/s10522-013-9462-3