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- Title
Cu(OH)<sub>x</sub>: Clay Catalyst Promoted Synthesis of 4,5-dihydro-1,2,4-oxadiazole at Room Temperature.
- Authors
Dar, Bashir Ahmad; Zaheer, Zahed; Fatema, Samreen; Farooqui, Mazahar
- Abstract
An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4- oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature. The cyclo-addition reaction is carried out between imine and oxime using an easy protocol where nitrile oxides are produced insitu from aldoximes and reacted with imines to construct 1,2,4-oxadiazolines in good yield and tremendous purity. Cu(OH)x-Clay catalyst shows excellent catalytic activity for the formation of 1,2,4-oxadiazole. The technique is practically uncomplicated, inexpensive, and excellent with wide range of functional group tolerance to generate structurally different 1,2,4-oxadiazoles. The prepared catalyst was investigated by XRD and SEM techniques. The final products of synthesized compound were characterized by FTIR, NMR spectroscopy and mass spectrometry.
- Subjects
COPPER catalysts; OXADIAZOLES; TEMPERATURE effect
- Publication
Orbital: The Electronic Journal of Chemistry, 2017, Vol 9, Issue 5, p378
- ISSN
1984-6428
- Publication type
Article
- DOI
10.17807/orbital.v9i5.1062