We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and properties of 2′,3′-anhydro derivatives of (2′-5′)-oligoadenylates containing modified heterobases.
- Authors
Kulak, T.; Tsibul′skaya, I.; Tkachenko, O.; Kalinichenko, E.; Kolbanova, E.; Krasinskaya, T.; Kukharchik, N.
- Abstract
New analogs of natural (2′-5′)-oligoadenylates containing ribavirin or BAP-riboside fragments in addition to adenine 2′,3′-anhydronucleoside units were obtained. The synthesized compounds were highly stable to enzymatic hydrolysis by snake venom phosphodiesterase. It was shown that ribavirin-containing (2′-5′)-oligonucleotides could be used for elimination of pathogenic raspberry ringspot virus in culture in vitro of microrunners of black current and cherry.
- Subjects
OLIGOADENYLATES; CHEMICAL derivatives; VENOM; RIBOSIDES; PHOSPHODIESTERASES
- Publication
Chemistry of Natural Compounds, 2013, Vol 49, Issue 4, p716
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-013-0715-9