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- Title
Assesment of Total CA[sup 2+] Handling for Excitation-Contraction Coupling in Beating Left Ventricle.
- Authors
Araki, Junichi; Shimizu, Juichiro; Iribe, Gentaro; Mohri, Satoshi; Kiyooka, Takahiko; Osima, Yu; Fujinaka, Waso; Doi, Yumiko; Suga, Hiroyuki
- Abstract
We have aimed to assess total Ca[sup 2+] handling in excitation-contraction coupling in a beating left ventricle (LV). Our newly developed integrative analysis method utilizes the internal Ca[sup 2+] recirculation fraction (RF), O[sub 2] consumption (V[sub O[sub 2]]) for Ca[sup 2+] handling, and O[sub 2] cost of Emax (contractility index) of the LV. We have obtained the O[sub 2] cost of Emax from V[sub O[sub 2]] measured at different contractility levels, and have combined the cost with RF calculated from the beat-constant of the exponential decay component of the postextrasystolic potentiation. Our method calculates the unknown total Ca[sup 2+] handling from the RF and the "Ca[sup 2+] handling V[sub O[sub 2]". The calculated total Ca[sup 2+] handling fell between 30 and 110 µmol/kg, depending on contractility and pathological conditions. The present method also enable's reasonable assessment of futile Ca[sup 2+] cycling and of the Ca[sup 2+] reactivity of Emax. Our method seems useful to better understanding of the pathophysiology of total Ca[sup 2+] handling in a beating heart.
- Subjects
LEFT heart ventricle; HEART beat
- Publication
Journal of Mechanics in Medicine & Biology, 2001, Vol 1, Issue 2, p123
- ISSN
0219-5194
- Publication type
Article
- DOI
10.1142/S0219519401000180