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- Title
Occupational airborne contamination in South Brazil: 2. Oxidative stress detected in the blood of workers of incineration of hospital residues.
- Authors
Possamai, F. P.; Avila Jr, S.; Budni, P.; Backes, P.; Parisotto, E. B.; Rizelio, V. M.; Torres, M. A.; Colepicolo, P.; Filho, D. Wilhelm
- Abstract
One of the most useful methods for elimination of solid residues of health services (SRHS) is incineration. However, it also provokes the emission of several hazardous air pollutants such as heavy metals, furans and dioxins, which produce reactive oxygen species and oxidative stress. The present study, which is parallel to an accompanied paper (Ávila Jr. et al., this issue), investigated several enzymatic and non-enzymatic biomarkers of oxidative stress in the blood (contents of vitamin E, lipoperoxidation = TBARS, reduced glutathione = GSH, oxidized glutathione = GSSG, and activities of glutathione S-transferase = GST, glutathione reductase = GR, glutathione peroxidase = GPx, catalase = CAT and superoxide dismutase = SOD), in three different groups (n = 20 each) exposed to airborne contamination associated with incineration of SRHS: workers directly (ca. 100 m from the incinerator) and indirectly exposed (residents living ca. 5 km the incineration site), and controls (non-exposed subjects). TBARS and GSSG levels were increased whilst GSH, TG and α-tocopherol contents were decreased in workers and residents compared to controls. Increased GST and CAT activities and decreased GPx activities were detected in exposed subjects compared to controls, while GR did not show any difference among the groups. In conclusion, subjects directly or indirectly exposed to SRHS are facing an oxidative insult and health risk regarding fly ashes contamination from SRHS incineration.
- Subjects
SOUTH Brazil; OXIDATIVE stress -- Risk factors; INCINERATORS &; the environment; PHYSIOLOGICAL effects of air pollution; HAZARDOUS substance exposure; RISK management in health facilities; ENZYMATIC analysis; BIOMARKERS
- Publication
Ecotoxicology, 2009, Vol 18, Issue 8, p1158
- ISSN
0963-9292
- Publication type
Article
- DOI
10.1007/s10646-009-0387-1