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- Title
IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.
- Authors
Song, Xinyang; Zhu, Shu; Shi, Peiqing; Liu, Yan; Shi, Yufang; Levin, Steven D; Qian, Youcun
- Abstract
Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor family. Here we show that IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C activated downstream signaling through IL-17RE-IL-17RA complex for the induction of genes encoding antibacterial peptides as well as proinflammatory molecules. IL-17C was upregulated in colon epithelial cells during infection with Citrobacter rodentium and acted in synergy with IL-22 to induce the expression of antibacterial peptides in colon epithelial cells. Loss of IL-17C-mediated signaling in IL-17RE-deficient mice led to lower expression of genes encoding antibacterial molecules, greater bacterial burden and early mortality during infection. Together our data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
- Subjects
INTERLEUKINS; CELL receptors; MUCOUS membranes; INTESTINES; PEPTIDES; CITROBACTER; MORTALITY; NATURAL immunity; EPITHELIAL cells
- Publication
Nature Immunology, 2011, Vol 12, Issue 12, p1151
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2155