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- Title
Effect of Nocturnal Oxygen Therapy on Nocturnal Hypoxemia and Sleep Apnea Among Patients With Chronic Obstructive Pulmonary Disease Traveling to 2048 Meters: A Randomized Clinical Trial.
- Authors
Tan, Lu; Latshang, Tsogyal D.; Aeschbacher, Sayaka S.; Huber, Fabienne; Flueck, Deborah; Lichtblau, Mona; Ulrich, Stefanie; Hasler, Elisabeth D.; Scheiwiller, Philipp M.; Ulrich, Silvia; Bloch, Konrad E.; Furian, Michael
- Abstract
Key Points: Question: Can nocturnal oxygen therapy prevent hypoxemia and sleep apnea among lowlanders with chronic obstructive pulmonary disease when traveling to high altitude? Findings: In this randomized crossover trial of 32 lowlanders with chronic obstructive pulmonary disease, nocturnal oxygen therapy improved their mean nocturnal oxygen saturation and apnea-hypopnea index during a night at 2048 m. Nocturnal oxygen therapy also reduced the incidence of altitude-induced adverse health effects requiring medical treatment or descent to lower altitude by 85% compared with placebo. Meaning: Patients with chronic obstructive pulmonary disease may benefit from nocturnal oxygen therapy during travel to high altitude because it reduces nocturnal hypoxemia, sleep disordered breathing, and other adverse health effects. This randomized clinical trial evaluates whether nocturnal oxygen therapy (NOT) prevents nocturnal hypoxemia and breathing disturbances among lowlanders with chronic obstructive pulmonary disease (COPD) in the first night of a stay at 2048 m and reduces the incidence of altitude-related adverse health effects. Importance: There are no established measures to prevent nocturnal breathing disturbances and other altitude-related adverse health effects (ARAHEs) among lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high altitude. Objective: To evaluate whether nocturnal oxygen therapy (NOT) prevents nocturnal hypoxemia and breathing disturbances during the first night of a stay at 2048 m and reduces the incidence of ARAHEs. Design, Setting, and Participants: This randomized, placebo-controlled crossover trial was performed from January to October 2014 with 32 patients with COPD living below 800 m with forced expiratory volume in the first second of expiration (FEV1) between 30% and 80% predicted, pulse oximetry of at least 92%, not requiring oxygen therapy, and without history of sleep apnea. Evaluations were performed at the University Hospital Zurich (490 m, baseline) and during 2 stays of 2 days and nights each in a Swiss Alpine hotel at 2048 m while NOT or placebo treatment was administered in a randomized order. Between altitude sojourns, patients spent at least 2 weeks below 800 m. Data analysis was performed from January 1, 2015, to December 31, 2018. Intervention: During nights at 2048 m, NOT or placebo (room air) was administered at 3 L/min by nasal cannula. Main Outcomes and Measures: Coprimary outcomes were differences between NOT and placebo intervention in altitude-induced change in mean nocturnal oxygen saturation (SpO2) as measured by pulse oximetry and apnea-hypopnea index (AHI) measured by polysomnography during night 1 at 2048 m and analyzed according to the intention-to-treat principle. Further outcomes were the incidence of predefined ARAHE, other variables from polysomnography results and respiratory sleep studies in the 2 nights at 2048 m, clinical findings, and symptoms. Results: Of the 32 patients included, 17 (53%) were women, with a mean (SD) age of 65.6 (5.6) years and a mean (SD) FEV1 of 53.1% (13.2%) predicted. At 490 m, mean (SD) SpO2 was 92% (2%) and mean (SD) AHI was 21.6/h (22.2/h). At 2048 m with placebo, mean (SD) SpO2 was 86% (3%) and mean (SD) AHI was 34.9/h (20.7/h) (P <.001 for both comparisons). Compared with placebo, NOT increased SpO2 by a mean of 9 percentage points (95% CI, 8-11 percentage points; P <.001), decreased AHI by 19.7/h (95% CI, 11.4/h-27.9/h; P <.001), and improved subjective sleep quality measured on a visual analog scale by 9 percentage points (95% CI, 0-17 percentage points; P =.04). During visits to 2048 m or within 24 hours after descent, 8 patients (26%) using placebo and 1 (4%) using NOT experienced ARAHEs (P <.001). Conclusions and Relevance: Lowlanders with COPD experienced hypoxemia, sleep apnea, and impaired well-being when staying at 2048 m. Because NOT significantly mitigated these undesirable effects, patients with moderate to severe COPD may benefit from preventive NOT during high altitude travel. Trial Registration: ClinicalTrials.gov Identifier: NCT02150590
- Subjects
OBSTRUCTIVE lung disease treatment; ALTITUDES; HYPOXEMIA; CONFIDENCE intervals; CROSSOVER trials; FISHER exact test; OXIMETRY; OXYGEN in the body; OXYGEN therapy; RESEARCH funding; STATISTICAL sampling; SLEEP apnea syndromes; PULSE oximeters; LOGISTIC regression analysis; RANDOMIZED controlled trials; TREATMENT effectiveness; DATA analysis software; DESCRIPTIVE statistics; NASAL cannula; FORCED expiratory volume
- Publication
JAMA Network Open, 2020, Vol 3, Issue 6, pe207940
- ISSN
2574-3805
- Publication type
Article
- DOI
10.1001/jamanetworkopen.2020.7940