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- Title
Utilidad y limitaciones del tamiz neonatal para hipotiroidismo congénito.
- Authors
CALZADA-LEÓN, RAÚL; GÓMEZ-VÁZQUEZ, VICTORIA; DE JESÚS RIVERA-HERNÁNDEZ, ALEIDA; LUZ RUIZ-REYES, MARÍA DE LA; VALLES-SÁNCHEZ, VICTORIA EUGENIA
- Abstract
Neonatal screening for congenital hypothyroidism is a method that allows the identification of the majority of patients with congenital hypothyroidism. However, there are false positive and false negative results, the main causes being: (i) exogenous false negatives: problems in the technique of obtaining the sample and filter paper handling, children of mothers with Graves' disease, maternal hyperiodinemia (contrast media, iodinated bacteriostatic solutions, ingestion of drugs with a high iodine content); (ii) endogenous false negatives: hypothyroidism of hypothalamic or hypophyseal origin, ectopic nodule, tissue transporter deficiency of thyroid hormones, late thyroid-stimulating hormone elevations (intrauterine growth retardation, prematurity, hypoxia, neonatal severe illness, genetic syndromes, thyroid-stimulating hormone decrease by drugs [steroids, dopamine] or malnutrition), inflammatory cytokines; (iii) exogenous false positive: metoclopramide, domperidone, dopamine, lithium, perchlorate, interferon alpha, phenobarbital, phenytoin, rifampicin, carbamazepine, propylthiouracil, amiodarone, propranolol, corticoids, tamoxifen, valproic acid, ethionamide, aminoglutethimide, sulfonamides, and sulfonylureas: (iv) endogenous false positives: Down's syndrome. If the confirmatory results are not absolutely congruent, the patient should be referred to a pediatric endocrinologist immediately. The initiation of treatment in the first two weeks of life will prevent alterations in cognitive function, but in all patients, malformations and associated dysfunctions should be sought.
- Publication
Revista Mexicana de Endocrinología, Metabolismo y Nutrición, 2017, Vol 4, Issue 2, p89
- ISSN
2339-9643
- Publication type
Article