We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The theoretical description for omeprazole electrochemical determination, assisted by the composite poly(1,2,4-triazole)-Ag<sub>2</sub>O<sub>2</sub>.
- Authors
Tkach, Volodymyr V.; Kushnir, Marta V.; Ivanushko, Yana G.; Ostapchuk, Valentyna G.; Melnychuk, Svitlana P.; de Oliveira, Sílvio C.; Parchenko, Volodymyr V.; Aksyonova, Ilona I.; Odyntsova, Vira M.; Yagodynets', Petro I.; Kormosh, Zholt O.; Luganska, Olga V.
- Abstract
Introduction: Omeprazole is one of the most used proton-blocking molecules applied in the gastric ulcer treatment. Its blocking effect is achieved by the presence of both acidic and basic nitrogen heteroatoms in its composition. Nevertheless, due to its collateral effects, which may be moderate to severe, the development of its electrochemical determination is really actual. Methods: In this work, we describe theoretically the possibility of omeprazole electrochemical determination, assisted by the composite, containing the silver (I, III) oxide as an active substance and the polymer of 1,2,4-triazolic derivative as a mediator. In this case, the omeprazole molecule is gradually oxidized yielding firstly phenolic and then quinonic derivative. The pyridinic nitrogen is oxidized later. Results: The electroanalytical process is described by a trivariant equation-set, analysis of which confirms the efficiency of the composite of poly(1,2,4-triazole) with Ag2O2. The electrochemical oscillations are also possible, being realized beyond the detection limit. Conclusion: The composite of poly(1,2,4-triazole) with Ag2O is suitable for omeprazole electrochemical determination both in vivo and in vitro.
- Subjects
OMEPRAZOLE; STOMACH ulcers; DETECTION limit; ELECTROCHEMICAL sensors; CONDUCTING polymers; POLYMERS
- Publication
Revista Colombiana de Ciencias Químico-Farmacéuticas, 2022, Vol 51, Issue 3, p1284
- ISSN
0034-7418
- Publication type
Article
- DOI
10.15446/rcciquifa.v51n3.107385