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- Title
Clinical Validity of the Mattis Dementia Rating Scale in Differentiating Mild Cognitive Impairment in Parkinson's Disease and Normative Data.
- Authors
Bezdicek, Ondrej; Michalec, Jiri; Nikolai, Tomas; Havránková, Petra; Roth, Jan; Jech, Robert; Růžička, Evžen
- Abstract
Background/Aims: The aim of the present study was to provide normative data and determine the validity of the Czech version of the Mattis Dementia Rating Scale 2 (czDRS-2) in screening for mild cognitive impairment in Parkinson's disease (PD-MCI) based on the Movement Disorder Society (MDS) Level II criteria. Methods: For validation purposes, 41 healthy controls (HC), 46 patients with PD-NI (Parkinson's disease, no impairment) and 41 patients with PD-MCI (all groups assessed by the MDS Level II criteria for PD-MCI) were matched according to age and education. Results: With screening and diagnostic cutoff scores determined at ≤139 points, the czDRS-2 showed a sensitivity of 78% and a specificity of 88% in the detection of PD-MCI versus HC and a sensitivity of 78% and a specificity of 76% in the detection of PD-MCI versus PD-NI. The AUC (95% confidence interval) for the czDRS-2 was 84% (75-93) and 82% (73-91), respectively. We report percentile values for 286 subjects from the Czech population stratified by education level. Conclusion: Our results show that the czDRS-2 is a valid instrument at Level I for screening PD-MCI and support its construct validity and diagnostic equivalence in a cross-cultural setting. © 2015 S. Karger AG, Basel
- Subjects
CZECH Republic; PARKINSON'S disease diagnosis; ACADEMIC medical centers; COGNITIVE testing; CONFIDENCE intervals; NEUROPSYCHOLOGICAL tests; RESEARCH methodology; PARKINSON'S disease; PROBABILITY theory; PSYCHOLOGICAL tests; RESEARCH funding; STATISTICS; DATA analysis; EDUCATIONAL attainment; PREDICTIVE tests; RECEIVER operating characteristic curves; RESEARCH methodology evaluation; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test
- Publication
Dementia & Geriatric Cognitive Disorders, 2015, Vol 39, Issue 5/6, p303
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000375365